STEP 1 : Semaglutide Treatment Effect in People with Obesity
STEP 1 : Semaglutide Treatment Effect in People with Obesity
Rationale : Obesity is a global health challenge with few pharmacologic options. Whether
adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of
2.4 mg (once weekly) as an adjunct to lifestyle intervention has not been confirmed.
Abstract
Participants
Eligible patients were 18 years of age or older
BMI > 30 or greater or 27 (with hypertension, OSA, CVD or dyslipidemia)
Self-reported unsuccessful dietary efforts to lose weight
Outcome
The coprimary endpoints were the percentage change in body weight and weight reduction of at least 5%
Semaglutide 2.4 mg SQ once a week versus Placebo. Estimated treatment difference, -12.4% ; 95% CI, -13.4 to -11.5; P value < 0.001
Practice Changing Pearls
Among adults with overweight or obesity (without diabetes), once-weekly subcutaneous semaglutide plus lifestyle intervention was associated with substantial, sustained, clinically relevant mean weight loss of 14.9%, with 86% of participants attaining at least 5% weight loss.
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Reference
Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002.
