Secondary hypertension mnemonic

A simple mnemonic for recalling the causes of secondary hypertension is CHARPLES. It is worth noting that most of the secondary causes of hypertension are of endocrine origin. Perturbations in each endocrine gland can contribute to secondary hypertension.

Causes of secondary hypertension

  • C : Conn’s syndrome (primary hyperaldosteronism), Cushing’s syndrome, Congenital Adrenal Hyperplasia.
  • H : Hyperparathyroidism, Hyperthyroidism
  • A : Aortic coarctation, Adrenal carcinoma
  • R : Renovascular hypertension, Reninoma, Renal parenchymal disease
  • P : Pheochromocytoma
  • L : Liddle’s syndrome, Licorice
  • E : Estrogen pills (oral contraceptive pill)
  • S : Sleep Apnea

The mechanism of secondary hypertension

What is pseudohyperaldosteronism?

These are endocrine conditions that present with some of the clinical features of primary hyperaldosteronism (hypertension and hypokalemia) but do not exhibit the expected increase in plasma aldosterone to plasma renin ratio. Patients with pseudohyperaldosteronism have low levels of both aldosterone and renin.

ConditionMechanism
Liddle’s syndromeA gain-of-function mutation of the gene encoding the amiloride-sensitive epithelial sodium chloride transporter
Gordon syndrome (Familial hyperkalemic hypertension)A gain of function mutation of the thiazide-sensitive sodium-chloride co-transporter in the distal nephron. Unlike other causes of pseudohyperaldosteronism, Gordon Syndrome is associated with hyperkalemia instead of hypokalemia.
Defects in adrenal steroidogenesis Deficiency of 11beta-hydroxylase enzyme results in a build-up of 11-Deoxycorticosterone (which has intrinsic mineralocorticoid activity)
Cushing’s syndromeExcess cortisol binds to the mineralocorticoid receptor due to saturation of the 11beta-hydroxysteroid dehydrogenase 2 enzyme. See cortisol to cortisone shunt
Congenital Apparent mineralocorticoid excessAn autosomal recessive condition characterized by an inactivating mutation of the 11beta-hydroxysteroid dehydrogenase 2 enzyme
Excessive intake of licorice, grapefruits or carbenoxolone. Medication induced apparent mineralocorticoid excessInhibition of 11beta-hydroxysteroid dehydrogenase 2. Glycyrrhizic acid inhibits 11beta-hydroxysteroid dehydrogenase 2 enzyme. Glycyrrhizic acid is present in the root of the licorice plant (Glycyrrhiza glabra).
Medication-inducedCorticosteroids and contraceptives
Congenital Adrenal Hyperplasia11beta-hydroxylase and 17alpha-hydroxylase deficiency leads to a buildup of 11-Deoxycorticosterone (intrinsic mineralocorticoid activity)

References

Armanini D, Calò L, Semplicini A. Pseudohyperaldosteronism: pathogenetic mechanisms. Crit Rev Clin Lab Sci. 2003 Jun;40(3):295-335.

Images(s) Courtesy

MyEndoConsult

Recent Posts

Mnemonic for hormones

Mnemonic for hormones A collection of mnemonics for anterior and posterior pituitary hormones, hypothalamic hormones, sex steroids, and other adrenal hormones. Simplified memory aid for

Read More »

Pituitary stalk thickening

Pituitary stalk thickening Causes of pituitary stalk thickening include infiltrative conditions and tumors. A simple mnemonic for recalling the etiology is STALLC. Causes of a

Read More »

Horner syndrome mnemonic

Horner syndrome mnemonic Horner’s syndrome classically presents with anhidrosis, ptosis, miosis, and enophthalmos. The simple mnemonic, SAMPLE can be used to recall both the causes

Read More »
Table of Contents