The first hormone to be isolated. The term “endocrine”, which refers to the secretory product of “ductless glands” coined by E.A Sharpey-Schafer and George Oliver
Secretin isolated from the duodenum.
Edward Kendall isolated thyroxine in crystalline form
Human Growth Hormone
Herbert Evans and Joseph Long discover growth hormone.
James Collip isolates parathyroid hormone
Gonadotropins (Prolan A and B)
Bernhard Zondek and Selmar Ascheim isolate gonadotropins
Thyroid Stimulating Hormone
Bernhard Zondek and Selmar Ascheim isolate LH and FSH. Stricker and Grueter isolate prolactin. Aron, Loeb, and Basset describe the action of TSH.
Oscar Riddle et al identified and isolated prolactin (mammotropin).
Butenandt isolates progesterone
Ernst Laqueur isolates testosterone
Cortisone (Compound E)
Edward Kendall isolates cortisone (an adrenal steroid)
1940 and 1942
LH and ACTH
Choh Hao Li isolates LH in 1940. Chao Hao Li and Sayers isolate ACTH
Choh Hao Li and Evans isolate FSH
Vincent du Vigneaud synthesizes oxytocin
Hirsch discovers calcitonin
Bradbury, Smyth, and Snell isolate beta-endorphin.
Frederick Banting and John Mcleod
Frederick Banting and John Mcleod were both awarded with the Nobel Prize in Physiology or Medicine. They demonstrated the glucose lowering effects of insulin two years earlier.
Nobel Prize in Chemistry (isolation of progesterone and research on sex hormones).
Nobel Prize in Physiology or Medicine (for his discovery of the part played by the anterior pituitary hormone involved in glucose metabolism. Description of the “Houssay phenomenon”)
Nobel Prize in Physiology or Medicine (for his discovery of cortisone)
Vincent du Vigneaud
Nobel Prize in Chemistry (being the first to synthesize a peptide hormone — oxytocin)
Luis Frederico Leloir
Nobel Prize in Chemistry (biosynthesis of carbohydrates)
Earl Wilbur Sutherland Jr.
Nobel Prize in Physiology or Medicine (discovery of the mechanisms of action of hormones)
Nobel Prize in Physiology or Medicine (development of the artificial insemination – in vitro fertilization)
Robert Lefkowitz and Brian Kobilka
Nobel Prize in Chemistry (Extensive research of G-protein-coupled receptors)