HORMONES

1895

Epinephrine (Adrenaline)

The first hormone to be isolated. The term “endocrine”, which refers to the secretory product of “ductless glands” coined by E.A Sharpey-Schafer and George Oliver

1902

Secretin

Secretin isolated from the duodenum.

1914

Thyroxine

Edward Kendall isolated thyroxine in crystalline form 

1920

Human Growth Hormone

Herbert Evans and Joseph Long discover growth hormone.

1925

Parathyroid Hormone

James Collip isolates parathyroid hormone

1928

Gonadotropins (Prolan A and B)

Bernhard Zondek and Selmar Ascheim isolate gonadotropins

1929

Thyroid Stimulating Hormone

Estrogen

Bernhard Zondek and Selmar Ascheim isolate LH and FSH. Stricker and Grueter isolate prolactin. Aron, Loeb, and Basset describe the action of TSH. 

1933

Prolactin

Oscar Riddle et al identified and isolated prolactin (mammotropin).

1934

Progesterone

Butenandt isolates progesterone

1935

Testosterone

Ernst Laqueur isolates testosterone

1935

Cortisone (Compound E)

Edward Kendall isolates cortisone (an adrenal steroid)

1940 and 1942

LH and ACTH

Choh Hao Li isolates LH in 1940. Chao Hao Li and Sayers isolate ACTH

1949

FSH

Choh Hao Li and Evans isolate FSH

1953

Oxytocin

Vincent du Vigneaud synthesizes oxytocin

1963

Calcitonin

Hirsch discovers calcitonin

1975

Beta-Endorphin

Bradbury, Smyth, and Snell isolate beta-endorphin.

NOBEL PRIZES

1923

Frederick Banting and John Mcleod

Frederick Banting and John Mcleod were both awarded with the Nobel Prize in Physiology or Medicine. They demonstrated the glucose lowering effects of insulin two years earlier.

1939

Adolf Butenandt

Nobel Prize in Chemistry (isolation of progesterone and research on sex hormones).

1947

Bernardo Houssay

Nobel Prize in Physiology or Medicine (for his discovery of the part played by the anterior pituitary hormone involved in glucose metabolism. Description of the “Houssay phenomenon”)

1950

Edward Kendall

Nobel Prize in Physiology or Medicine (for his discovery of cortisone)

1955

Vincent du Vigneaud

Nobel Prize in Chemistry (being the first to synthesize a peptide hormone — oxytocin)

1970

Luis Frederico Leloir

Nobel Prize in Chemistry (biosynthesis of carbohydrates)

1971

Earl Wilbur Sutherland Jr.

Nobel Prize in Physiology or Medicine (discovery of the mechanisms of action of hormones)

2010

Robert Edwards

Nobel Prize in Physiology or Medicine (development of the artificial insemination – in vitro fertilization)

2012

Robert Lefkowitz and Brian Kobilka

Nobel Prize in Chemistry (Extensive research of G-protein-coupled receptors)

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