WHI E + P

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial

• HRT should not be used for primary or secondary prevention of cardiovascular disease (AHA).

• HRT should not be used in menopausal women for primary or secondary prevention of coronary artery disease (ACOG).

• HRT increases the risk of CAD, breast cancer, and VTE, and reduces the risk of fragility fractures based on the results of this study.

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Reference

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321-33.

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