PCOS

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome

Clomiphene in combination with metformin does not improve live birth rates in women with PCOS, when compared to clomiphene alone.

Clomiphene citrate or comparable estrogen modulator (letrozole) is recommended as first-line treatment of anovulatory infertility in women with PCOS (Endocrine Society and ASRM)

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Reference

Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice LC, Leppert PC, Myers ER; Cooperative Multicenter Reproductive Medicine Network. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med. 2007 Feb 8;356(6):551-66.

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