JUPITER – Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

JUPITER – Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

• There were significant flaws with this study. Most importantly, the estimation of a treatment benefit favoring statins may have been overestimated due to the early termination of this study.

• No guidelines have been published advocating statin therapy for primary prevention in patients with baseline characteristics similar to this study cohort.

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Reference

Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008 Nov 20;359(21):2195-207.

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