Landmark Clinical Trials in Endocrinology

A collection of visual abstracts of landmark clinical trials in diabetes care and endocrinology.

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Important Trials in Diabetes and Endocrinology 2021 14 Topics

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Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass.

SURPASS-2: A Study of Tirzepatide Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

STEP 1 : Semaglutide Treatment Effect in People with Obesity

SOLOIST-WHF: Effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure.

SCORED : Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

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Reproductive Endocrinology 8 Topics

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WHI E + P

AMIGOS : Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility

HERS Study

KEEPS Study : Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial

PCOS (LETROZOLE STUDY)

FET

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Diabetes Mellitus 24 Topics

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ADVANCE : Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

ACCORD : Effects of intensive glucose lowering in type 2 diabetes

CANVAS : Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.

D2d TRIAL: Vitamin D Supplementation and Prevention of Type 2 Diabetes.

DCCT : The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

DPP: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The Diabetes Prevention Program

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Calcium and Bone Metabolism 7 Topics

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Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial

FIT : Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group

PTH(1-34) : Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

FRAME : Romosozumab Treatment in Postmenopausal Women with Osteoporosis

FREEDOM : Denosumab for prevention of fractures in postmenopausal women with osteoporosis

HORIZON : Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis

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Pituitary Disorders 2 Topics

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PASIREOTIDE B2305 STUDY GROUP : A 12-month phase 3 study of pasireotide in Cushing’s disease

COPEPTIN – A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus

Lipidology and Obesity 13 Topics

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RECORD: Rosiglitazone Evaluated for Cardiovascular Outcomes in oRal agent combination therapy for type 2 Diabetes mellitus

4S : The Scandinavian Simvastatin Survival Study

JUPITER – Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

IMPROVE-IT : Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

HPS3/TIMI55 : Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

HOPE-3 Trial : Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease

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8 Lessons
77 Topics

Diabetes and Endocrinology Trials

Course Content

Course Includes

Endocrinology Board Review QBank

Brief Reviews

glycemic index chart

How to start testosterone FTM

Orchidometer

Graves disease and pregnancy

Positive Chvostek Sign

Tirzepatide – A twincretin

Whipple triad

Metanephrines

Osteoporosis Medications (Mechanism of Action)

GKI regimen

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